职称：教授、博士生导师
学历：博士
E-mail:lujunxia@hbut.edu.cn
研究方向：
1） 细胞坏死程序性调控中重要信号传导蛋白的结构变化和互作机制
2） 神经退行性疾病相关的纤维化蛋白研究
3） 生物矿化和材料的研究，研究牙釉蛋白对牙釉质形成和骨质生成的调控，牙釉蛋白功能性高聚物结构，设计新型仿生材料。
4） 多肽纤维材料
5） 发展开发磁共振技术在生物医药和材料中的应用
基本信息：
陆珺霞，云顶国际8588yd教授、博士生导师，国家青年高层次人才获得者。国际磁共振协会（ISMAR2021-2025）理事会成员，中国生物物理学会生物磁共振学会理事会成员（2016-2020，2021-2025）。固态核磁研究淀粉样蛋白领域权威专家。本科毕业于复旦大学化学系，于美国迈阿密大学化学和生物化学系获得博士。2007-2011年在美国国立健康研究所从事博士后工作。2012-2015年期间先后在美国太平洋西北国家实验室和美国国立健康研究所从事研究员工作。以第一作者或通讯作者在Cell, PNAS, NatureCommunication, J. Am. Chem. Soc.等著名杂志发表论文近40篇。单篇引用近500次（Cell, 2013）。担任NatureCommunication, PNAS等著名杂志审稿人。
科研成果：
2018.1-2021.12 自然科学基金面上项目, 功能状态下牙釉蛋白结构的核磁共振研究
2017.7-2022.6 科技部重点研发项目, 线粒体内膜蛋白结构研究，子课题核磁技术研究线粒体内膜蛋白结构
2021.1-2024.12 自然科学基金面上项目，细胞坏死程序性调控中关键信号传导蛋白结构变化和互作机制研究
论文：
1. Wu, X. L. #; Hu, H. #; Dong, X. Q.; Zhang, J.; Wang, J.; Schwieters, C. D.; Liu, J.; Wu, G.X.; Li, B.; Lin, J. Y.; Wang, H. Y.* andLu, J. X.* (2021) The amyloid structure of mouse RIPK3 (Receptor interacting protein kinase 3) in cell necroptosis.Nat Commun. 12:1627 doi.org/10.1038/s41467-021-21881-2
2. Wu, X. L.#; Ma, Y.#; Zhao, K.#; Zhang, J.; Sun, Y.; Li, Y.; Dong, X.Q.; Hu, H.; Liu, J.; Wang, J.; Zhang, X.; Li, B.; Wang, H.; Li, D.; Sun, B.;Lu, J.X.* and Liu, C. * (2021) The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3.Proc. Natl. Acad. Sci. USA April 6, 2021 118 (14) e2022933118;https://doi.org/10.1073/pnas.2022933118
3. Zhuo, X. F.; Wang, J.; Zhang J.; Jiang L. L.; Hu, H. Y*. andLu, J. X*. (2020) Solid-state NMR reveals the structural transformation of the TDP-43 amyloidogenic region upon fibrillation.J. Am. Chem. Soc. 142, 7, 3412-3421.
4. Hu, H. #; Wu, X.L. #; Wu, G. X.; Nan, N.; Zhang J.; Zhu, X. X.; Zhang Y.; Shu Z. Q.; Liu, J.; Liu, X.Y.;Lu, J. X*. and Wang, H. Y.* (2020) RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif,Cell Death Differ. Jul 31. doi: 10.1038/s41418-020-0598-9
5. Song, R. #; Wu, X. #; Xue, B.; Yang, Y.; Huang, W.; Zeng, G.; Wang, J.; Li, W.; Cao, Y.; Wang, W*.;Lu, J. X.*and Dong, H.* (2019) Principles governing catalytic activity of self-assembled short peptides.J. Am. Chem. Soc. 141, 223-231.
6. Lu, J.X.; Qiang, W.; Yau W.M.; Schwieters, C. D.; Meredith, S.C. and Tycko R.* (2013) Molecular structure of β-amyloid fibrils in Alzheimer’s disease brain tissueCell 154,1257-1268 (with video paperflick)
7. Qiang,W.; Yau, W.M.;Lu,J.X.; Collinge, J.; and Tycko, R. *, (2017)Structural Variation in Amyloid-β Fibrils from Alzheimer's Disease Clinical Subtypes Nature 541, 217-221
8. Jing Liu, Xia-lian Wu, Yu-teng Zeng, Zhi-heng Hu andJun-xia Lu* Solid-state NMR studies of amyloids (2023)Structure Cell Press. 10.1016/j.str.2023.01.005Review
9. Jing Zhang, Yushi Bai, Jian Wang, Bing Li, Stefan Habelitz andJun-xia Lu* (2022) Calcium interactions in amelogenin-derived peptide assemblyFront. Physiol.13:1063970
10. Yu-Teng Zeng, Lu-Lu Bi, Xiao-Feng Zhuo, Ling-Yun Yang, Bo Sun andJun-xia Lu* (2022) Different Intermolecular Interactions Drive NonpathogenicLiquid–Liquid Phase Separation and Potentially Pathogenic Fibril Formation by TDP-43 Int. J. Mol. Sci. 23,15227.
11. Jing-Yu Lin, Ming-Hui Sun, Jing Zhang, Meng Hu, Yu-Teng Zeng, Qian-Qian Yi, Jian Wang, Yun Bai, Yifeng Zhang*,Jun-Xia Lu* (2022) Solid-state NMR (SSNMR) Characterization of Osteoblast from Mesenchymal Stromal Cell Differentiation to Osteoblast Mineralization.Journal of bone and mineral research plus, Oct; 6(10): e10662
12. Dong, X. Q.; Lin, J. Y.; Wang, P. F.; Li, Y.; Wang, J.; Li, B.; Liao, J. andLu, J. X.* (2021) Solid-State NMR Studies of the Succinate-Acetate Permease from Citrobacter Koseri in Liposomes and Native Nanodiscs.Life, 11, 908.
13. Yi, C. Y. #; Xia, J. #; He, L#; Ling, Z. Y.; Wang, X. S.; Yan, Y.; Wang J. J.; Zhao, X. H.; Fan, W. G.; Sun, X. Y.; Zhang R. H.; Ye, S.; Zhang, R. G.; Ma, L. Y.; Zhang, Y.G.; Zhou, H. L.; Huang, Z.; Niu, J. Q.; Long, G*.;Lu, J. X*.; Zhong, J*.and Sun B*. (2020) Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody,Cell Mol. Immunol.Mar 31:1-11
14. Zhang, J.; Wang J.; Ma, C. W. andLu, J. X.* (2020) Hydroxyapatite formation coexists with amyloid-like self-assembly of human amelogenin.Int. J. Mol. Sci.21, 8, 2946.
15. Chu, Y. #; Dong, X. #; Kang, Y. J.; Liu, J.; Zhang, T.; Yang, C.; Wang, Z.; Shen, W.; Huo, H.; Zhuang, M.;Lu, J. X.* and Liu, Y.* (2020) The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.iscience, Oct 21; 23(11):101708.
16. Ma, C.W.; Zhang, J.; Dong, X.Q. andLu, J. X*. (2019). Amyloid structure of high-order assembly of Leucine-rich amelogenin revealed by solid-state NMR.J. Struct. Biol. 206, 29-35.
17. Arachchige, R. J.; Burton, S. D.;Lu, J. X.; Ginovska, B. Harding, L.K.; Taylor, M.E.; Tao, J.; Dohnalakova, A.; Tarasevich, B.; Bucko, G.W. and Shaw, W. J* (2018) Solid-state NMR identification of intermolecular interactions in amelogenin bound to hydroxyapatite,Biophys. J., Nov 6; 115(9):1666-1672 doi. 10.1016/j-bpj.2018.08.027
18. He, L.; Gu, W.; Wang, M.; Chang, X.; Sun, X.; Zhan,g Y.; Lin, X.; Yan, C.; Fan, W.; Su, P.; Wang, Y.; Yi, C.; Lin, G.; Li, L.; Jiang, Y.;Lu, J.X; Dong, C.; Wang, H.; Sun, B.*. (2018) Extracellular Matrix Protein 1 promotes follicular helper T cells differentiation and antibody production,Proc. Natl. Acad. Sci. USA 115(34):8621-8626. doi: 10.1073/pnas.1801196115,
19. Lu, J.X.*; Dong, X.Q. and Zhang, J.J. (2017) Solid-State Structure of Abeta (A beta) in Alzheimer's DiseaseProtein & Peptide Letters, 24(4), 322-330Review
20. Lu, J.X.; Bayro, M.J. and Tycko, R*. (2016) Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments,J. Biol. Chem. vol 291, No. 25, pp. 13098-13112
21. Scherpelz, K. P.;Lu, J.X.;Tycko R. and Meredith, S.C.* （2016）Preparation of Amyloid Fibrils Seeded from Brain and Meninges, Protein Amyloid Aggregation: Methods and Protocols,Methods in Molecular Biology, David Eliezer (ed.), vol. 1345, 299-311
22. Lu, J.X.; Burton, S.D.; Xu, Y.M.; Buchko G.W. and Shaw, W.J.* (2014)The flexible structure of the K24S28 region of Leucine-Rich Amelogenin Protein (LRAP) bound to apatites as a function ofsurface type, calcium, mutation, and ionic strengthFront. Physiol. 5, 254, 1-8
23. Lu, J.X.; Xu, Y.M. and Shaw, W.J.* (2013) Mineral Association Changes the Secondary Structure and Dynamics of AmelogeninJ. Dent. Res. 92, 1000-1004 (IF8.94)
24. Lu, J.X.; Xu, Y.M. and Shaw, W.J.* (2013) Phosphorylation and Ionic Strength Alter the LRAP-HAP interface in the N-terminusBiochemistry. 52, 2196-2205
25. Lu, J.X.; Sharpe S.; Yau, W.Y. and Tycko R.* (2010) Oligomerization State and Supramolecular Structure of the HIV-1 Vpu Protein Transmembrane Segment in Phospholipid BilayersProtein Sci. 19, 1877-1896
26. Lu, J.X.; Yau, W.Y. and Tycko R.* (2010) Evidence from solid state NMR for non-helical conformations in the transmembrane domain of the amyloid precursor proteinBiophys. J. 100, 711-719
27. Chu, S. D., Abu-Baker, S.,Lu, J.X. and Lorigan, G.A.* (2010) N-15 Solid-state NMR spectroscopic studies on phospholamban at its phosphorylated form at Ser-16 in aligned phospholipid bilayersBiochim. Biophys. Acta.-biomembranes1798 312-317
28. Abu-Baker, S. #,Lu, J.X. #, Chu, S.D., Shetty, K.K., Gor’kov, P.L., and Lorigan, G.A.* (2007) The structural topology of wild-type phospholamban in oriented lipid bilayers using N-15 solid-state NMR spectroscopyProtein Sci. 16, 2345-2349
29. Abu-Baker, S.,Lu, J.X., Chu, S.D., Brinn, C.C., Makaroff, C.A., and Lorigan, G.A.* (2007) Side chain and backbone dynamics of phospholamban in phospholipid bilayers utilizing H-2 and N-15 solid-state NMR spectroscopyBiochemsitry. 46, 11695-11706.
30. Lu, J.X., Blazyk J. and Lorigan, G. A.* (2006) Exploring membrane selectivity of the antimicrobial peptide KIGAKI using Solid-State NMR spectroscopyBiochim. Biophys. Acta. 1758, 1303-1313.
31. Lu, J.X., Damodaran, K. and Lorigan, G. A.* (2006) “Probing Membrane Topology by 1H-13C Heteronuclear Dipolar Solid-State NMR Spectroscopy”J. Magn. Reson. 178, 283-287.
32. Lu, J.X., Damodaran, K., Blazyk, J. and Lorigan, G. A.* “Solid-State NMR Relaxation Studies of the Interaction Mechanism of Antimicrobial Peptides with Phospholipid Bilayer Membranes”Biochemistry.(2005) 44, 10208-10217.
33. Lu, J.X., Caporini, M. A. and Lorigan, G. A. (2004) “The Effects of Cholesterol on Magnetically Aligned Phospholipid Bilayers: A Solid-State NMR and EPR Spectroscopy Study” J. Magn. Reson. 168: 18-30.
34. Li, S.,Lu, J.X., Gan, J. H., Wang, Y. H., Huang Z. X.* and Xia Z. X.* (2005) Structure of the F58W mutant of cytochrome b5: the mutation leads to multiple conformations and weakens stacking interactionsActa Crystallogr., Sect. D: Biol. Crystallogr. D61(2), 180-189.
35. Su, H.,Lu, J.X., Wang, Y. H., Ren, Y., Xie, Y. and Huang Z. X.* (2004) Study on the DME-cytochrome b(5) and its mutants at site of F58Chinese Sci. Bull. 49, 18, 1914-1919
36. Wang, W. H.,Lu, J.X., Yao P., Xie, Y. and Huang Z. X.* (2003) The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b(5)Protein Eng.16,12 1047-1054
37. Wang, Y. H.,Lu, J.X., Wang, W. H., Ren, Y., Xie, Y. and Huang Z. X.* (2002) Roles of Phe58 in Stabilizing Structure of Cytochrome b5Chinese Sci. Bull. 47, 24, 2063-2066.
